Investigating the angiogenic role of Murine Double Minute-2 in contractile muscle cells

研究小鼠 Double Minute-2 在收缩肌细胞中的血管生成作用

• 批准号: RGPIN-2017-05675
• 负责人: BIROT, Olivier
• 金额: $ 2.04万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630502
• 关键词: Investigating; angiogenic; role; Murine; Double

Capillaries are our smallest blood vessels. They are the site of exchanges between blood and cells. In skeletal muscles, capillaries play a crucial role in providing oxygen and nutrients to the active muscle cells. Angiogenesis is the very complex process of formation of new capillaries. Physical exercise is a well-known stimulus for skeletal muscle angiogenesis. One single bout of exercise stimulates the expression of signal molecules that regulate the process of muscle angiogenesis. In particular, these molecules act on endothelial cells, the cells forming the wall of the capillaries. In order to get more capillaries, these cells need to be activated so they can proliferate, migrate, and assembly together into new vessels. If the exercise stimulus is repeated daily over a few weeks, like during prolonged exercise training, new functional capillaries will be formed in skeletal muscle, and the muscle function, especially in response to exercise, will be improved.

毛细血管是我们最小的血管。它们是血液和细胞之间交换的场所。在骨骼肌中，毛细血管在为活跃的肌肉细胞提供氧气和营养方面起着至关重要的作用。血管生成是形成新毛细血管的非常复杂的过程。体育锻炼是骨骼肌血管生成的一种众所周知的刺激。一次运动就能刺激调节肌肉血管生成过程的信号分子的表达。特别地，这些分子作用于内皮细胞，即形成毛细血管壁的细胞。为了获得更多的毛细血管，这些细胞需要被激活，以便它们可以增殖，迁移和组装成新的血管。如果在几周内每天重复运动刺激，如在长时间的运动训练期间，骨骼肌中将形成新的功能性毛细血管，肌肉功能，特别是对运动的反应，将得到改善。