Investigating the angiogenic role of Murine Double Minute-2 in contractile muscle cells

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Capillaries are our smallest blood vessels. They are the site of exchanges between blood and cells. In skeletal muscles, capillaries play a crucial role in providing oxygen and nutrients to the active muscle cells. Angiogenesis is the very complex process of formation of new capillaries. Physical exercise is a well-known stimulus for skeletal muscle angiogenesis. One single bout of exercise stimulates the expression of signal molecules that regulate the process of muscle angiogenesis. In particular, these molecules act on endothelial cells, the cells forming the wall of the capillaries. In order to get more capillaries, these cells need to be activated so they can proliferate, migrate, and assembly together into new vessels. If the exercise stimulus is repeated daily over a few weeks, like during prolonged exercise training, new functional capillaries will be formed in skeletal muscle, and the muscle function, especially in response to exercise, will be improved.