Study of the mechanisms of pulse-pressure dependent regulation of vascular tone

脉压依赖性血管张力调节机制的研究

• 批准号: RGPIN-2017-04770
• 负责人: Thorin, Eric
• 金额: $ 2.04万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630506
• 关键词: Study; mechanisms; pulse; pressure; dependent

Pulsatile blood flow nourishes the organs and depends on cardiac contractility, peripheral resistances and large conductance artery stiffness. Few studies reported that pulsatile flow leads to better blood pressure regulation, kidney perfusion and a reduced inflammation. Neither the impact of pulsatile flow on cerebral blood flow (CBF) regulation, nor the molecular mechanisms involved in mechanosensing and mechanotransduction are known. We hypothesize that these physiological pathways are determinant and knowing them will help develop innovative diagnostic tools tracking CBF reactivity, that is believed to be at the basis of age-related cognitive decline when impaired.

脉动血流使器官搏动，并取决于心脏收缩力、外周阻力和大电导动脉僵硬度。很少有研究报道脉动流导致更好的血压调节，肾脏灌注和减少炎症。脉动流对脑血流（CBF）调节的影响，以及机械传感和机械转导的分子机制都是未知的。我们假设这些生理途径是决定性的，了解它们将有助于开发跟踪CBF反应性的创新诊断工具，这被认为是受损时与年龄相关的认知下降的基础。