The regulation of the intestinal epithelium and host-pathogen interactions by the constitutive androstane receptor

组成型雄甾烷受体对肠上皮和宿主-病原体相互作用的调节

• 批准号: RGPIN-2016-03842
• 负责人: Hirota, Simon
• 金额: $ 2.26万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630542
• 关键词: regulation; intestinal; epithelium; host; pathogen

Johne’s disease, a wasting condition in ruminants, is caused by infection with Mycobacterium avium subspecies paratuberculosis (MAP), which is transmitted via contaminated milk and through the fecal-oral route. Since signs and symptoms of Johne’s disease often take years to develop (during which MAP can be shed in the feces), it is difficult to implement traditional surveillance methods to reduce its spread. To limit the burden of infectious disease in livestock and natural ruminants we must understand the steps that lead to pathogen transmission, invasion and the host inflammatory response.

约翰氏病是反刍动物的一种消耗性疾病，由鸟分枝杆菌副结核亚种（MAP）感染引起，通过受污染的牛奶和粪口途径传播。由于约翰氏病的体征和症状通常需要数年才能发展（在此期间MAP可以在粪便中脱落），因此很难实施传统的监测方法来减少其传播。为了限制家畜和天然反刍动物的传染病负担，我们必须了解导致病原体传播、入侵和宿主炎症反应的步骤。