Roles of Malat1 in response to hypoxia

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Our team previously uncovered the long non-coding RNA Malat1 through NSERC-funded programs using parallel modifications in gene expression to screen for genes modulated upon aging and diet in tissues critical for lipid metabolism, namely liver and adipose. We recently demonstrated that low oxygen conditions robustly increase Malat1 gene expression through the stimulation of an AMPK/HIF-1? axis. Based on these novel findings, we propose to study the contribution of Malat1 in the modulation of cellular and physiological adaptations that take place in response to hypoxia, either triggered in low oxygen conditions, or through activation of lipopolysaccharide (LPS)-induced inflammation. Using both in vitro and in vivo models, we will: