Investigating the role of Ephrins and Eph receptors in circadian physiology

研究 Ephrins 和 Eph 受体在昼夜生理学中的作用

• 批准号: RGPIN-2015-04889
• 负责人: Mongrain, Valérie
• 金额: $ 4.15万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630587
• 关键词: Investigating; role; Ephrins; Eph; receptors

The circadian timing system governs numerous endogenous physiological functions, which synchrony with the environment light-dark cycle determines the proper functioning of organisms. It is known that circadian rhythms emanate from a molecular transcriptional-translational feedback loop and that the synchronisation with the nychthemeron depends on the main endogenous clock (i.e., suprachiasmatic nucleus of the hypothalamus [SCN] in mammals). Yet, the manner by which the clock molecular feedback loop signals to output systems remains mostly unknown. The general hypothesis of this program is that the clock molecular machinery regulates circadian rhythmicity by controlling the expression and activity of elements shaping synaptic function.

昼夜节律系统调控着许多内源生理功能，这些功能与环境的明暗周期同步，决定了生物体的正常功能。众所周知，昼夜节律由分子转录-翻译反馈环发出，并且与nychhemes的同步性依赖于主要的内源性时钟(即哺乳动物的下丘脑[SCN]的视交叉上核)。然而，时钟分子反馈回路向输出系统发出信号的方式大多仍不清楚。这个程序的一般假设是，时钟分子结构通过控制形成突触功能的元件的表达和活动来调节昼夜节律。