Investigating the role of Ephrins and Eph receptors in circadian physiology

点击翻译按钮获取中文摘要

The circadian timing system governs numerous endogenous physiological functions, which synchrony with the environment light-dark cycle determines the proper functioning of organisms. It is known that circadian rhythms emanate from a molecular transcriptional-translational feedback loop and that the synchronisation with the nychthemeron depends on the main endogenous clock (i.e., suprachiasmatic nucleus of the hypothalamus [SCN] in mammals). Yet, the manner by which the clock molecular feedback loop signals to output systems remains mostly unknown. The general hypothesis of this program is that the clock molecular machinery regulates circadian rhythmicity by controlling the expression and activity of elements shaping synaptic function.