Identification and characterization of the factor Va binding site on prothrombin.

凝血酶原上因子 Va 结合位点的鉴定和表征。

• 批准号: RGPIN-2017-05347
• 负责人: Kim, Paul
• 金额: $ 1.89万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630602
• 关键词: Identification; characterization; factor; Va; binding

Upon vascular injury, the coagulation system is activated in order to stop the blood loss and begin the process of wound healing and damage repair. The clotting system consists of enzyme complexes that sequentially activate downstream enzyme complexes. One characteristic in common is that these complexes all contain 1) enzyme, 2) cofactor, 3) calcium, and 4) negatively charged cell surface. In all instances, even though the enzyme is able to act on the substrate alone, the presence of its cofactor enhances the reaction by 10

在血管损伤时，凝血系统被激活以停止失血并开始伤口愈合和损伤修复的过程。凝血系统由依次激活下游酶复合物的酶复合物组成。一个共同的特征是这些复合物都含有1）酶，2）辅因子，3）钙，和4）带负电荷的细胞表面。在所有情况下，即使酶能够单独作用于底物，其辅因子的存在使反应增强10