UNDERSTANDING THE ROLE OF MITOCHONDRIAL QUALITY CONTROL

了解线粒体质量控制的作用

• 批准号: RGPIN-2016-03932
• 负责人: Burelle, Yan
• 金额: $ 2.26万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630629
• 关键词: UNDERSTANDING; ROLE; MITOCHONDRIAL; QUALITY; CONTROL

Mitochondrial quality control (mQC), which refers to the mechanisms governing the regulated degradation of mitochondrial components, is an emerging facet in the field of mitochondrial biology. Indeed, several mQC mechanisms, the best known being mitophagy, have been uncovered recently, but their role in various cell types, their level of inter-relation, and their physiological relevance in vivo, remain poorly understood. This program aims to answer these questions using striated muscle and immune cells which have different designs and functions. We will focus on two mQC mechanisms:

线粒体质量控制（mitochondrialqualitycontrol，mQC）是近年来线粒体生物学领域的一个新的研究方向，它是一种调控线粒体组分降解的机制。事实上，最近已经发现了几种mQC机制，最著名的是线粒体自噬，但它们在各种细胞类型中的作用，它们的相互关系水平以及它们在体内的生理相关性仍然知之甚少。该计划旨在使用具有不同设计和功能的横纹肌和免疫细胞来回答这些问题。我们将重点介绍两种mQC机制：