Cortico-limbic Circuits for Learning and Memory

学习和记忆的皮质边缘回路

• 批准号: RGPIN-2016-04364
• 负责人: Phillips, Anthony
• 金额: $ 2.26万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630735
• 关键词: Cortico; limbic; Circuits; Learning; Memory

This renewal extends a basic research project focused on neural mechanisms of synaptic plasticity required for learning and memory. We have made significant progress in understanding the role of synaptic Long-Term Depression (LTD) in the learning of fear conditioning and other aspects of memory including stress-induced disruption of spatial memories. A better understanding of the role of LTD in cognition will enhance our understanding of the biological bases of learning and memory.

这次更新扩展了一个基础研究项目，重点是学习和记忆所需的突触可塑性的神经机制。我们在理解突触长期抑制（LTD）在学习恐惧条件反射和记忆的其他方面（包括压力诱导的空间记忆中断）中的作用方面取得了重大进展。更好地理解LTD在认知中的作用将增强我们对学习和记忆的生物学基础的理解。