Subtype-Specific Connectivity of Local Inhibitory Interneurons in the Motor Cortex

运动皮层局部抑制性中间神经元的亚型特异性连接

• 批准号: RGPIN-2017-05308
• 负责人: Chen, Simon
• 金额: $ 2.19万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630752
• 关键词: Subtype; Specific; Connectivity; Local; Inhibitory

The brain is a network that consists of diverse types of neurons and their connections provide the framework for information flow in the brain. Mapping neuronal connectivity within mammalian brains has been a long-standing and important goal in neuroscience because a clearer understanding of communication between and within brain regions will be key to uncovering the new brain functions such as formation and acquisition of complex movements. Mammals possess a remarkable ability to learn and consistently execute a wide range of movements with high levels of control. The primary motor cortex has been shown to produce voluntary movement and store movement-related memories, allowing new motor patterns to be learned. Considerable research efforts have been aimed at understanding how the motor cortex enables the generation and acquisition of new movements. Although a substantial body of knowledge pertaining to neural network dynamics within the motor cortex during motor skill learning has been explored, the fundamental question of which regions and which neurons the motor cortex communicates with remains elusive. Therefore, understanding the basic anatomical and functional wiring diagram of the motor system, with cell-type specificity, is an essential step in improving our understanding of the cortical mechanisms enabling motor movements and motor learning.

大脑是由不同类型的神经元组成的网络，它们的连接为大脑中的信息流提供了框架。绘制哺乳动物大脑中的神经元连接一直是神经科学的一个长期而重要的目标，因为更清楚地了解大脑区域之间和内部的通信将是揭示新的大脑功能的关键，例如复杂运动的形成和获得。哺乳动物具有非凡的学习能力，并能在高度控制的情况下持续执行各种各样的动作。初级运动皮层已经被证明可以产生自主运动并存储与运动相关的记忆，从而可以学习新的运动模式。相当多的研究工作旨在了解运动皮层如何使新运动的产生和获得。虽然大量的知识涉及运动技能学习过程中运动皮层内的神经网络动力学已经被探索，运动皮层与哪些区域和哪些神经元通信的基本问题仍然难以捉摸。因此，了解运动系统的基本解剖学和功能布线图，以及细胞类型特异性，是提高我们对实现运动运动和运动学习的皮质机制的理解的重要步骤。