Respiratory and neurovascular adaptation to physiological stress

呼吸和神经血管对生理应激的适应

• 批准号: RGPIN-2017-03749
• 负责人: Sheel, Andrew
• 金额: $ 5.03万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630777
• 关键词: Respiratory; neurovascular; adaptation; physiological; stress

The heart, circulation, lungs, and chest wall act together in a highly coordinated fashion. While studying each system in isolation can provide valuable information, examining how these systems work together provides a more comprehensive understanding of basic physiology. My program seeks to further our understanding of the anatomic and physiological relationships between these systems using a human model. Biological sex has been rarely considered when exploring cardiorespiratory interactions however, important differences have now been identified. For example, skeletal muscle fatigability differs between the sexes. Women are usually less fatigable than men during single-limb contractions but little is known about sex differences in the fatigability of the respiratory musculature. The

心脏、循环、肺和胸壁以高度协调的方式共同作用。虽然孤立地研究每个系统可以提供有价值的信息，但研究这些系统如何协同工作可以更全面地了解基本生理学。我的计划旨在进一步了解这些系统之间的解剖和生理关系，使用人体模型。在探索心肺相互作用时很少考虑生物性别，但现在已经确定了重要的差异。例如，骨骼肌的易疲劳性在性别之间是不同的。在单肢收缩时，女性通常比男性更不容易疲劳，但对呼吸肌系统疲劳性的性别差异知之甚少。的