Regulation of mammalian skeletal muscle lipid metabolism: the role of perilipin proteins

哺乳动物骨骼肌脂质代谢的调节：周脂质蛋白的作用

• 批准号: RGPIN-2016-04300
• 负责人: Peters, Sandra
• 金额: $ 2.55万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630852
• 关键词: Regulation; mammalian; skeletal; muscle; lipid

The long-term objective of my ongoing NSERC-funded research program is to understand the underlying mechanisms and the regulation of mammalian enzymes/proteins that regulate triglyceride (fat or lipid) metabolism in muscle. We know that dysregulation of skeletal muscle lipid metabolism results in deterioration of cell signaling and disruptions in cellular energy homeostasis, and therefore understanding the underlying mechanisms of regulation of these processes would be a first step to identifying therapeutic targets and alternate therapies (e.g., exercise).

我正在进行的NSERC资助的研究计划的长期目标是了解调节肌肉中甘油三酯（脂肪或脂质）代谢的哺乳动物酶/蛋白质的潜在机制和调节。我们知道骨骼肌脂质代谢的失调导致细胞信号传导的恶化和细胞能量稳态的破坏，因此理解这些过程的潜在调节机制将是确定治疗靶点和替代疗法（例如，锻炼）。