Modulating bacterial cell metabolism to enhance the efficacy of antibiotics

调节细菌细胞代谢以增强抗生素的功效

• 批准号: 373749
• 负责人: Stokes Jonathan M
• 金额: $ 10.2万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2019-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=373749&lang=en
• 关键词: Antibiotic Combination Therapy; Antibiotic Tolerance And Resistance; Functional Genomics; Metabolomics; Transcriptomics; Translatomics

Antibiotics kill bacteria by poisoning their cellular machines, which perform essential functions like copying DNA, making proteins, or building a cell envelope. Bacteria can survive antibiotic treatment by (a) mutating the drug target so that the antibio

抗生素通过毒害它们的细胞机器来杀死细菌，这些细胞机器执行复制DNA、制造蛋白质或构建细胞包膜等基本功能。细菌可以通过(a)使药物靶点发生突变，使抗生素在抗生素治疗中存活