Neuroendocrine regulation and transduction mechanisms in pituitary hormone release in fish

鱼类垂体激素释放的神经内分泌调节和转导机制

• 批准号: RGPIN-2015-05636
• 负责人: Chang, John
• 金额: $ 3.57万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630882
• 关键词: Neuroendocrine; regulation; transduction; mechanisms; pituitary

Pituitary luteinizing hormone (LH) and growth hormone (GH) are important regulators of reproduction and growth in vertebrates. Multiple stimulatory and inhibitory brain hypothalamic neurohormones in turn control LH and GH secretion and production. Thus, studying the mechanisms by which the effects of these neurohormones are manifested at the level of the pituitary cells is important for understanding the physiological control of growth and reproduction. In goldfish, LH- and GH-cells share common, as well as distinct, regulators. For example, two gonadotropin-releasing hormones (GnRH2 and GnRH3), pituitary adenylate cyclase-activating polypeptide (PACAP) and ghrelin (gGRLN) stimulate both LH and GH secretion while dopamine (DA) inhibits LH, but stimulates GH, release. In contrast, GH-releasing hormone (gGHRH) stimulates GH, but attenuates LH, secretion. Understanding how the intracellular cellular changes (signal tranduction events) effected by these neurohormones interact to mediate their influences on LH and GH release and synthesis is integral to studying the physiological control of reproduction and growth. We have previously focused on how extracellular and intracellular Ca

垂体黄体生成素（LH）和生长激素（GH）是脊椎动物繁殖和生长的重要调节剂。多种刺激性和抑制性大脑下丘脑神经激素依次控制 LH 和 GH 的分泌和产生。因此，研究这些神经激素在垂体细胞水平上的作用机制对于理解生长和繁殖的生理控制非常重要。在金鱼中，LH 细胞和 GH 细胞具有共同且不同的调节因子。例如，两种促性腺激素释放激素（GnRH2 和 GnRH3）、垂体腺苷酸环化酶激活多肽 (PACAP) 和生长素释放肽 (gGRLN) 刺激 LH 和 GH 分泌，而多巴胺 (DA) 抑制 LH，但刺激 GH 释放。相反，生长激素释放激素 (gGHRH) 会刺激生长激素，但会减弱黄体生成素的分泌。了解这些神经激素影响的细胞内细胞变化（信号转导事件）如何相互作用以介导它们对 LH 和 GH 释放和合成的影响，对于研究生殖和生长的生理控制至关重要。我们之前重点关注细胞外和细胞内 Ca