Neuroendocrine regulation and transduction mechanisms in pituitary hormone release in fish

黄体生成素（LH）和生长激素（GH）是脊椎动物生殖和生长的重要调节因子。多种刺激性和抑制性脑下丘脑神经激素反过来控制LH和GH的分泌和产生。因此，研究这些神经激素的作用在垂体细胞水平上表现出来的机制对于理解生长和生殖的生理控制是重要的。在金鱼中，LH-和GH-细胞共享共同的，以及不同的，监管机构。例如，两种促性腺激素释放激素（GnRH 2和GnRH 3），垂体腺苷酸环化酶激活多肽（PACAP）和生长素释放肽（gGRLN）刺激LH和GH分泌，而多巴胺（DA）抑制LH，但刺激GH释放。与此相反，生长激素释放激素（gGHRH）刺激生长激素，但减弱LH分泌。了解这些神经激素影响的细胞内细胞变化（信号转导事件）如何相互作用，以介导它们对LH和GH释放和合成的影响，是研究生殖和生长生理控制不可或缺的。我们以前关注细胞外和细胞内Ca

Pituitary luteinizing hormone (LH) and growth hormone (GH) are important regulators of reproduction and growth in vertebrates. Multiple stimulatory and inhibitory brain hypothalamic neurohormones in turn control LH and GH secretion and production. Thus, studying the mechanisms by which the effects of these neurohormones are manifested at the level of the pituitary cells is important for understanding the physiological control of growth and reproduction. In goldfish, LH- and GH-cells share common, as well as distinct, regulators. For example, two gonadotropin-releasing hormones (GnRH2 and GnRH3), pituitary adenylate cyclase-activating polypeptide (PACAP) and ghrelin (gGRLN) stimulate both LH and GH secretion while dopamine (DA) inhibits LH, but stimulates GH, release. In contrast, GH-releasing hormone (gGHRH) stimulates GH, but attenuates LH, secretion. Understanding how the intracellular cellular changes (signal tranduction events) effected by these neurohormones interact to mediate their influences on LH and GH release and synthesis is integral to studying the physiological control of reproduction and growth. We have previously focused on how extracellular and intracellular Ca