Impact of Endometrial Lipids on Uterine Histotroph Composition and Preimplantation Conceptus Development in Dairy Cattle

繁殖是乳品可持续性的关键组成部分，因为它影响牛群的整体产奶量及其生产效率。然而，哺乳期奶牛的妊娠损失很大，并且损害了奶牛场的繁殖效率和盈利能力。着床前孕体（胚胎和相关的胚外膜）的延长是牛成功妊娠的先决条件，并取决于子宫内膜分泌的组织营养素。尽管如此，大约三分之一的存活囊胚在发育的第四周结束时未能伸长和存活。奶牛繁殖效率的提高需要制定策略，以尽量减少早期胚胎死亡率，这反过来又需要更好地阐明早期发育生物学中的关键事件。

Reproduction is a critical component of dairy sustainability because it impacts the overall milk yield in a herd and its’ production efficiency. Pregnancy loss in lactating cows, however, is substantial and impairs reproductive efficiency and profitability of dairy farms. Elongation of the preimplantation conceptus (embryo and associated extra-embryonic membranes) is a prerequisite for successful pregnancy in cattle and depends on histotroph secretion by the endometrium. Nonetheless, approximately one third of viable blastocysts fail to elongate and survive by the end of the fourth week of development. Improvements in reproductive efficiency of dairy cows will require the development of strategies to minimize early embryonic mortality, which in turn will require a better elucidation of critical events in early developmental biology.