Understanding the assembly, trafficking and signalling of G protein-coupled receptor dimers.

了解 G 蛋白偶联受体二聚体的组装、运输和信号传导。

• 批准号: 368722
• 负责人: Hbert Terence E
• 金额: $ 79.42万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=368722&lang=en
• 关键词: Biosensors; Conformational Profiling; Crispr; Drug Discoveru; G Protein-Coupled Receptors; G Proteins; Proteomics; Receptor Trafficking; Signal Profiling; Signalling Complex Assembly

Most of the drugs currently used to treat heart failure and related diseases (including beta-blockers) are directed against the largest family of cell surface receptors (which transduce signals outside of the cell into activity inside the cell), the so-ca

目前用于治疗心力衰竭和相关疾病的大多数药物（包括β受体阻滞剂）都是针对最大的细胞表面受体家族（将细胞外的信号转变成细胞内的活性），即