Unraveling the pathophysiology of feline hypertrophic cardiomyopathy - an interdisciplinary approch

揭示猫肥厚性心肌病的病理生理学——跨学科方法

• 批准号: RGPIN-2017-04399
• 负责人: Fonfara, Sonja
• 金额: $ 1.82万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630985
• 关键词: Unraveling; pathophysiology; feline; hypertrophic; cardiomyopathy

Feline hypertrophic cardiomyopathy (HCM) is a common, spontaneous disease of adult, predominantly male cats. A genetic cause is reported, but cats can have a mutation and not develop the disease and cats without mutation can present with disease characteristics. Also, other factors that influence the disease are so far not known. HCM is characterized by thickening of the left cardiac chamber wall, with structural and functional changes. This results in increased stiffness and dysfunction of the heart and can cause arrhythmia, thrombus formation and heart failure. However, the clinical signs and progression of the disease are highly variable, and little agreement exists about the clinical and pathological disease parameter.

猫肥厚型心肌病是一种常见的自发性疾病，主要发生在成年公猫身上。据报道，这是一种遗传原因，但猫可以有突变，而不会患上这种疾病，而没有突变的猫可以表现出疾病的特征。此外，影响疾病的其他因素迄今尚不清楚。HCM的特征是左心室壁增厚，伴有结构和功能改变。这会导致心脏僵硬和功能障碍增加，并可能导致心律失常、血栓形成和心力衰竭。然而，该疾病的临床体征和进展是高度可变的，并且关于临床和病理疾病参数存在很少的一致性。