Role of ionotropic glutamate receptors and synaptic plasticity in development of novel fast-acting antidepressants.

离子型谷氨酸受体和突触可塑性在新型速效抗抑郁药开发中的作用。

• 批准号: 369102
• 负责人: Phillips Anthony G
• 金额: $ 70.5万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-09-01 至 2022-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=369102&lang=en
• 关键词: Animal Models; Biological Psychiatry; Depression; Dopamine; Electrophysiology; Glutamate; Microdialysis; Neuropsychopharmacology; Prefrontal Cortex

Depression is a debilitating mental disorder affecting over 350 million people globally and is associated with high personal and socioeconomic burden. Efficacy of classical antidepressant medications, including selective serotonin reuptake inhibitors and

抑郁症是一种使人衰弱的精神障碍，影响全球超过3.5亿人，并与高个人和社会经济负担有关。经典抗抑郁药物的疗效，包括选择性5-羟色胺再摄取抑制剂和