Pharmacologically Dissecting the Contributions of the Oxytocin and Opioid Systems in the Cognitive, Affective and Behavioural Processes Underlying Human Affiliation

从药理学角度剖析催产素和阿片类药物系统在人类归属感的认知、情感和行为过程中的贡献

• 批准号: RGPIN-2017-04433
• 负责人: Bartz, Jennifer
• 金额: $ 2.33万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=631265
• 关键词: Pharmacologically; Dissecting; Contributions; Oxytocin; Opioid

Humans have a fundamental need to secure at least a few stable, positive, significant interpersonal relationships; as Baumeister and Leary (1995) note, “a great deal of human behavior and thought is caused by this fundamental interpersonal motive”. Indeed, humans are distinguished by a repertoire of skills that facilitate social connection: our ability to i) identify the thoughts, feelings and intentions of others, or mentalize, ii) coordinate, or synchronize, our actions with others to achieve common goals, and iii) override self-interest to cooperate with and help others in need. Given the importance of relationships, it is thought that biological mechanisms have evolved to support the initiation and maintenance of these bonds. In this program of research, I will integrate methods from neuroscience, cognitive science and experimental psychology to evaluate the functional role of the oxytocin and opioid systems in the cognitive, affective and behavioral processes that support human affiliation.

人类有一种基本的需求，需要确保至少几个稳定的、积极的、重要的人际关系；正如Baumeister和Leary(1995)所指出的那样，“人类的大量行为和思想都是由这种基本的人际动机引起的”。事实上，人类的独特之处在于一系列促进社会联系的技能：我们有能力：i)识别他人的想法、感觉和意图，或将其心灵化；ii)协调或同步我们与他人的行动，以实现共同目标；iii)凌驾于自身利益之上，与其他有需要的人合作和帮助。鉴于关系的重要性，人们认为生物机制已经进化为支持这些纽带的启动和维持。在这个研究项目中，我将结合神经科学、认知科学和实验心理学的方法，评估催产素和阿片系统在支持人类从属关系的认知、情感和行为过程中的功能作用。