Organized responsive soft matter: films and colloids

有组织的响应性软物质：薄膜和胶体

• 批准号: RGPIN-2017-05887
• 负责人: Winnik, francoise
• 金额: $ 6.56万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632313
• 关键词: Organized; responsive; soft; matter; films

Nanotechnology affects our daily activities, including medical care. Diagnostics tools as well as medical imaging or drug formulations rely on polymer nanoparticles that protect their load against the harsh in-vivo environment. We recently discovered that poly(betaines) can translocate the cell membrane, bypassing endocytosis, which results in high drug uptake. This success encouraged us to deepen our fundamental understanding of the interactions of poly(betaines) with the cell membrane, using model phospholipids vesicles and interfaces. Specifically, we will assess the effects of the topology (linear, cyclic, star-like) of the poly(betaine) chains on their uptake by the cell membrane. Simulations and a few experiments indicate the importance of chain topology in drug delivery, but the topic is mostly unexplored. The preparation of topologically pure polymers is difficult. With our previous experience in the successful synthesis of cyclic and star nonionic polymers, we are well prepared to overcome the challenge.

纳米技术影响着我们的日常活动，包括医疗保健。诊断工具以及医学成像或药物制剂依赖于聚合物纳米颗粒，这些聚合物纳米颗粒可以保护其负载免受恶劣的体内环境的影响。我们最近发现，聚（甜菜碱）可以易位细胞膜，绕过内吞作用，这导致高药物摄取。这一成功鼓励我们加深我们的基本理解的聚（甜菜碱）与细胞膜的相互作用，使用模型磷脂囊泡和接口。具体而言，我们将评估的拓扑结构（线性，环状，星形）的聚（甜菜碱）链上的细胞膜吸收的影响。模拟和一些实验表明，在药物输送链的拓扑结构的重要性，但该主题是大多未探索。拓扑纯聚合物的制备是困难的。凭借我们之前成功合成环状和星星型非离子聚合物的经验，我们已经做好了充分的准备来克服挑战。