Structural Mapping Protein-Surface Interface by Proteomics

通过蛋白质组学绘制蛋白质-表面界面结构图

• 批准号: RGPIN-2017-06073
• 负责人: Sun, Bingyun
• 金额: $ 1.6万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632601
• 关键词: Structural; Mapping; Protein; Surface; Interface

The ability to study proteins and membrane proteins in a small number of cells is critical to investigate stem-cell development and the cause of cancer. Proteome is the entire protein complement of a biological system. Proteomic study of a small number of stem cells and cancer initiating cells enables comprehensive characterization of protein functions in complex biological events that these cells participate in. The obtained knowledge can provide molecular guidance for disease treatment and prevention.

研究少量细胞中的蛋白质和膜蛋白的能力对于研究干细胞发育和癌症的原因至关重要。蛋白质组是生物系统的全部蛋白质组成。对少量干细胞和癌症起始细胞的蛋白质组学研究使得能够全面表征这些细胞参与的复杂生物事件中的蛋白质功能。所获得的知识可以为疾病的治疗和预防提供分子指导。