Discovery of new catalytic reactions through mechanistically guided screening

通过机械引导筛选发现新的催化反应

• 批准号: RGPIN-2015-05019
• 负责人: Newman, Stephen
• 金额: $ 1.82万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=632787
• 关键词: Discovery; new; catalytic; reactions; through

Research in the Newman group focuses on the application of modern technologies to the advancement of fundamental and applied chemistry. In particular, we are exploring the use of high throughput experimentation (HTE) and flow chemistry platforms for the synthesis of valuable molecules. This proposal focuses on the application of HTE to the discovery of homogeneously catalyzed reactions of readily available building blocks. Being a young research group, our goal is to take on high impact projects with the intention of establishing a unique, world-class research program. This will occur through three phases: 1) Reaction discovery, optimization, and mechanism elucidation; 2) Application to the synthesis of pharmaceuticals and biomass-derived bulk chemicals; and 3) Use of our increased understanding of catalysis for further reaction development. This research proposal describes a 5 year plan for phase 1, discovery of new chemical reactions, including a new C–C cross-coupling reaction, an atom economical olefin-aldehyde coupling, and an N

纽曼小组的研究重点是现代技术在基础化学和应用化学进步中的应用。特别是，我们正在探索使用高通量实验（HTE）和流动化学平台来合成有价值的分子。该建议的重点是应用HTE发现容易获得的结构单元的均相催化反应。作为一个年轻的研究小组，我们的目标是承担高影响力的项目，旨在建立一个独特的，世界一流的研究计划。这将通过三个阶段进行：1）反应发现，优化和机理阐明; 2）应用于药物和生物质衍生的大宗化学品的合成;以及3）使用我们对催化的进一步理解反应发展。该研究计划描述了第一阶段的5年计划，发现新的化学反应，包括新的C-C交叉偶联反应，原子经济的烯烃-醛偶联反应和N-甲基-N-