Transport modeling for multi-modality contrast-enhanced imaging

动态增强(DCE)成像的使用正迅速成为了解各种疾病和干预措施的重要工具。这在从工程和化学到结构和细胞生物学的其他领域也是至关重要的。目前，DCE成像能够通过血流和灌流来评估组织功能。我们最新的工作表明，在氧合不良和高压的组织中，当前动力学模型的可靠性大大降低。结合更多有关组织微环境状况的信息，将有助于阐明更多的疾病过程，提高DCE成像的诊断价值，并评估药物输送机制的有效性和对靶向干预的反应。间质液体压力(IFP)是获得非侵入性流体压力(IFP)的一个有价值的特征-IFP的当前测量需要一种基于针的方法，该方法只能在可接触的组织位置使用，很难重复。我们实验室的初步工作表明，这些类型的参数可以从非侵入性DCE成像中获得。

The use of dynamic contrast-enhanced (DCE) imaging is rapidly becoming an important tool to understand a variety of diseases and interventions. This is critical in other fields as well ranging from engineering and chemistry to structural and cell biology. At present DCE imaging is able to assess tissue functionality through blood flow and perfusion. Our most recent work has shown that the reliability of current kinetic models is much reduced in tissues with poor oxygenation and high pressure. Incorporating more information on the micro-environmental conditions of tissue would help illuminate more disease processes and increase the value of DCE imaging for diagnostic purposes and to assess the efficacy of drug delivery mechanisms and the response to targeted interventions.Interstitial fluid pressure (IFP) is one feature that would be valuable to acquire non-invasively—current measurements of IFP require a needle-based approach that can only be used on accessible tissue locations and is difficult to repeat. Preliminary work from our lab indicates that these types of parameters can be derived from non-invasive DCE imaging.