Transport modeling for multi-modality contrast-enhanced imaging

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The use of dynamic contrast-enhanced (DCE) imaging is rapidly becoming an important tool to understand a variety of diseases and interventions. This is critical in other fields as well ranging from engineering and chemistry to structural and cell biology. At present DCE imaging is able to assess tissue functionality through blood flow and perfusion. Our most recent work has shown that the reliability of current kinetic models is much reduced in tissues with poor oxygenation and high pressure. Incorporating more information on the micro-environmental conditions of tissue would help illuminate more disease processes and increase the value of DCE imaging for diagnostic purposes and to assess the efficacy of drug delivery mechanisms and the response to targeted interventions.Interstitial fluid pressure (IFP) is one feature that would be valuable to acquire non-invasively—current measurements of IFP require a needle-based approach that can only be used on accessible tissue locations and is difficult to repeat. Preliminary work from our lab indicates that these types of parameters can be derived from non-invasive DCE imaging.