Proton Magnetic Resonance of Biological Systems

生物系统的质子磁共振

• 批准号: RGPIN-2015-04513
• 负责人: MacKay, Alex
• 金额: $ 3.5万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=633299
• 关键词: Proton; Magnetic; Resonance; Biological; Systems

Nuclear magnetic resonance (NMR), with its combined sensitivity to both structure and dynamics, is a well-proven technique for the study of biological systems. Since life processes occur in solution, the proton NMR of water in these systems should contain important information. Indeed, medical magnetic resonance imaging (MRI) relies on the exquisite contrast provided by differences in signal from tissue water between different types of normal tissue and between normal and pathological tissue. However, our understanding of the fundamental origins of this exquisite MR contrast is still at a primitive stage.

核磁共振是研究生物系统的一种行之有效的技术，它对结构和动力学都有很高的敏感性。由于生命过程发生在溶液中，这些体系中水的质子核磁共振应该包含重要信息。事实上，医学磁共振成像(MRI)依赖于不同类型的正常组织之间以及正常组织和病理组织之间来自组织水的信号的差异所提供的精致对比。然而，我们对这种精致的MR对比的根本起源的理解仍处于原始阶段。