Rhinovirus impairs physiological and immunological lung development and causes exacerbation of allergic airways disease

鼻病毒损害肺部的生理和免疫发育并导致过敏性气道疾病恶化

• 批准号: DP110101706
• 负责人: Prof Peter Sly
• 金额: $ 38.68万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP110101706
• 关键词: Rhinovirus; impairs; physiological; immunological; lung

Rhinovirus (RV) infections account for around 90 per cent of asthma exacerbations, yet the mechanisms behind this are unknown. This project will use mouse models to study the effects of early life RV infection and allergic sensitisation on respiratory and immunological development, with the expectation that early life RV infection disrupts anitgen presenting cell function.

鼻病毒（RV）感染约占哮喘急性发作的90%，但其背后的机制尚不清楚。该项目将使用小鼠模型研究早期RV感染和过敏性致敏对呼吸和免疫发育的影响，期望早期RV感染破坏抗原呈递细胞功能。