Design of self-assembling materials for challenging drug formulations and implant devices

用于具有挑战性的药物配方和植入装置的自组装材料的设计

• 批准号: RGPIN-2017-06945
• 负责人: Mateescu, MirceaAlexandru
• 金额: $ 1.75万
• 依托单位: Université du Québec à Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638262
• 关键词: Design; self; assembling; materials; challenging

The conceptual core of the proposed research is that “Minor modifications can generate Major changes” in certain self-assembling polymeric excipient features. Several polyhydroxylic materials may present strong interchain self-assembling stabilized by hydrogen association. Starch is a natural polysaccharide exhibiting different morphological forms - double helix (B type) or single helix (V type) that coexist with disordered regions. The V-type structures present a relatively hydrophobic inner surface that can hold iodine or even some fatty molecules. Among the current drugs, many of them are very low soluble (i.e. non-steroidal anti-inflammatory drugs, as ibuprofen) and consequently difficult to formulate for controlled delivery. Other drugs present a very high solubility (such as the antidiabetic metformin) and are also difficult to formulate for sustained release. Thus, their efficiency is low and they can produce undesirable side effects due to their liberation at improper sites.

拟议研究的概念核心是某些自组装聚合物赋形剂特征中的“微小修改可产生重大变化”。几种多羟基材料可能存在强链间自组装稳定的氢缔合。淀粉是一种天然多糖，具有不同的形态-双螺旋（B型）或单螺旋（V型），它们与无序区域共存。V型结构具有相对疏水的内表面，可以容纳碘或甚至一些脂肪分子。在目前的药物中，它们中的许多是非常低可溶性的（即非甾体抗炎药，如布洛芬），因此难以配制用于控制递送。其他药物具有非常高的溶解度（如抗糖尿病的二甲双胍），也难以配制成缓释剂。因此，它们的效率低，并且由于它们在不适当的位置释放，它们可能产生不希望的副作用。