Grid cell dysfunction and impairment of the medial entorhinal cortex correlate with path integration deficits in a mouse model of Alzheimer's disease

网格细胞功能障碍和内侧内嗅皮层损伤与阿尔茨海默病小鼠模型中的路径整合缺陷相关

• 批准号: 386449
• 负责人: Ying Johnson
• 金额: $ 1.27万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-12-01 至 2018-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=386449&lang=en
• 关键词: Alzheimer'S Disease; Amyloid Beta Plaques; Electrophysiology; Entorhinal Cortex; Grid Cells; Hippocampus; Memory; Mental Health; Spatial Navigation; Systems Neuroscience

Alzheimer's disease (AD) is a neurodegenerative disease that causes spatial memory impairment, where AD patients show symptoms of disorientation and difficulty navigating. Characterizing spatial memory deficits in patients is difficulty due to the multimo

阿尔茨海默病(AD)是一种导致空间记忆障碍的神经退行性疾病，AD患者表现出定向障碍和导航困难的症状。由于多发性记忆障碍，描述患者的空间记忆缺陷是困难的