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Using CRISPR/Cas9 knockout systems to identify synthetic interactions with hexosamine biosynthesis and N-glycan remodelling pathway enzymes to inhibit cancer cell growth

Using CRISPR/Cas9 knockout systems to identify synthetic interactions with hexosamine biosynthesis and N-glycan remodelling pathway enzymes to inhibit cancer cell growth
使用 CRISPR/Cas9 敲除系统识别己糖胺生物合成和 N-聚糖重塑途径酶的相互作用,以抑制癌细胞生长
批准号:
386540
负责人:
Chirila Alexandra
金额:
$1.27万
依托单位:
依托单位国家:
加拿大
项目类别:
Studentship Programs
财政年份:
2017
资助国家:
加拿大
项目状态:
已结题
起止时间:
2017-12-01 至 2018-12-01

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英文摘要
Cancer research has shifted towards developing therapies that target multiple points of a cell, as cancer cells often adapt to treatment and develop resistance. A method of identifying multiple targets uses synthetic lethal interactions, where mutations o
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