Mathematical Genomics

数学基因组学

• 批准号: CRC-2015-00257
• 负责人: Sankoff, David
• 金额: $ 14.57万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642675
• 关键词: Mathematical; Genomics

Focusing on combinatorial algorithms, probability modeling and extensive collaborative analysis of flowering plant genomes, we propose to provide a comprehensive formal understanding of a wide range of phenomena connected to the evolution of chromosomes, specifically at the level of gene order. This development of a battery of formal combinatorial, mathematical and statistical tools will be thoroughly integrated with our work on the genomes of a large number of individual species. Our approaches should directly impact thinking within computational biology and should lead to useful ideas for biological research, as well as new discoveries about the genomes of many flowering plants.

专注于组合算法，概率建模和显花植物基因组的广泛的协作分析，我们建议提供一个全面的正式了解广泛的现象连接到染色体的进化，特别是在基因顺序的水平。这一系列正式的组合、数学和统计工具的开发将与我们对大量单个物种基因组的研究彻底结合起来。我们的方法应该直接影响计算生物学的思维，并为生物学研究带来有用的想法，以及对许多开花植物基因组的新发现。