Carbohydrate Chemistry

碳水化合物化学

• 批准号: 1000230406-2014
• 负责人: Lowary, Todd
• 金额: $ 14.57万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642941
• 关键词: Carbohydrate; Chemistry

Carbohydrates present on the outer surfaces of bacteria and other microbes play key roles in a large number of disease processes. The proposed research program will use carbohydrate chemistry to provide molecules that can be used to explore the function of carbohydrates (or glycans) in mycobacterial diseases, including tuberculosis, as well as food-borne infections including those caused by infection with campylobacters and E. coli. These investigations will form the basis of exciting developments that will lead to novel therapeutics, diagnostics and vaccines and in turn benefit Canada and the world.

碳水化合物存在于细菌和其他微生物的外表面，在许多疾病过程中起着关键作用。拟议的研究计划将使用碳水化合物化学来提供分子，这些分子可用于探索碳水化合物（或聚糖）在分枝杆菌疾病（包括结核病）以及由弯曲杆菌和大肠杆菌感染引起的食源性感染中的功能。这些研究将成为令人兴奋的发展的基础，这些发展将导致新的治疗方法、诊断方法和疫苗，从而使加拿大和世界受益。