Paleogenetics

古遗传学

• 批准号: 1000227705-2011
• 负责人: Poinar, Hendrik
• 金额: $ 1.82万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=643183
• 关键词: Paleogenetics

We are developing a state-of-the-art facility, one of only a handful within Canada and North America, focused on the meticulous characterization of DNA and RNA from archival, forensic and fossil samples that span geologically significant time scales. This sequence data will be used to address a range of significant research themes including the evolution of pathogens particularly historically significant agents such as Black Death and HIV-1, that have altered the course of human history. We will use state of the art high throughput sequencing of DNA extracted from the arctic permafrost to map out bacterial, plant and animal communities across time, in the hope of understanding how climate change in the past effected their distribution and in turn aid us in thus developing a predictive model for monitoring impending change in a future warming Arctic. This has direct impact not only on the key animal and plant species currently living in the north, but the humans that depend upon them for their survival.

我们正在开发一个国家的最先进的设施，在加拿大和北少数之一， 该项目的重点是对档案、法医和化石样本中的DNA和RNA进行细致的表征，这些样本跨越了地质学上重要的时间尺度。这些序列数据将用于解决一系列重要的研究主题，包括病原体的进化，特别是历史上重要的病原体，如黑死病和HIV-1，它们改变了人类历史的进程。我们将使用从北极永久冻土中提取的DNA的最先进的高通量测序来绘制细菌，植物和动物群落，希望了解过去的气候变化如何影响它们的分布，从而帮助我们开发一个预测模型，用于监测未来变暖的北极即将发生的变化。这不仅直接影响到目前生活在北方的主要动物和植物物种，而且也影响到依赖它们生存的人类。