GCN5-directed acetylation of YY1 regulates the expression of dystrophin and associated proteins

GCN5 介导的 YY1 乙酰化调节肌营养不良蛋白和相关蛋白的表达

• 批准号: 382432
• 负责人: Menzies Keir
• 金额: $ 61.02万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-03-01 至 2023-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=382432&lang=en
• 关键词: Acetylation; Becker'S Muscular Dystrophy; Dystrophin; Gcn5; Lysine Deacetylase (Kdac) Inhibitors; Muscular Dystrophy; Yy1

Muscular dystrophy is a life-threatening muscular disorder, to which there is no cure. Part of the difficulty in treating this disorder is the fact that this is a genetic disease that affects key proteins that maintain muscle integrity. The purpose of thi

肌肉萎缩症是一种危及生命的肌肉疾病，目前尚无治愈方法。治疗这种疾病的部分困难在于，这是一种遗传性疾病，会影响维持肌肉完整性的关键蛋白质。这样做的目的