ConCRISPR: Conjugative delivery of a hybrid CRISPR/Tev nuclease system for specific microbiota modulation in the mammalian gut

ConCRISPR：混合 CRISPR/Tev 核酸酶系统的接合递送，用于哺乳动物肠道中特定微生物群的调节

• 批准号: 380426
• 负责人: Edgell David R
• 金额: $ 64.93万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-03-01 至 2023-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=380426&lang=en
• 关键词: Conjugative Plasmid; Crispr/Tevcas9 Nuclese; Designer Nuclease; Microbial Ecosystem Manipulation; Targeted Antimicrobial Therapeutic

The human microbiota, composing the bacteria that live on or in us, is crucial for human development, health and disease. The discovery of antibiotics transformed our ability to control the human microbiota and resulted in a dramatic increase in survival

人类的微生物群构成了生活在我们身上或体内的细菌，对人类的发展、健康和疾病至关重要。抗生素的发现改变了我们控制人类微生物区系的能力，并导致存活率显著提高。