Suppression of regulatory B cells by neutrophils in a model of multiple sclerosis

多发性硬化症模型中中性粒细胞对调节性 B 细胞的抑制

• 批准号: 381008
• 负责人: Vallières Luc
• 金额: $ 79.42万
• 依托单位: Universit Laval
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-03-01 至 2023-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=381008&lang=en
• 关键词: B Lymphocytes; Demyelinating Autoimmune Diseases; Experimental Autoimmune Encephalomyelitis; Multiple Sclerosis; Neuromyelitis Optica; Neutrophils

B cells contribute to multiple sclerosis (MS) and other autoimmune diseases in a variety of ways (e.g. by producing antibodies); depleting them improves clinical outcomes. However, current treatments deplete most B cells, including regulatory B cells (Bre

B细胞在多发性硬化症(MS)和其他自身免疫性疾病中以各种方式起作用(例如，通过产生抗体)；耗尽它们可以改善临床结果。然而，目前的治疗方法耗尽了大多数B细胞，包括调节性B细胞(Bre