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Decoding the impact of critically short telomeres on murine embryonic stem cell transcriptional signatures and cell fate commitment

Decoding the impact of critically short telomeres on murine embryonic stem cell transcriptional signatures and cell fate commitment
解码极短端粒对小鼠胚胎干细胞转录特征和细胞命运承诺的影响
批准号:
391487
负责人:
Chu Tsz Wai
金额:
$0.07万
依托单位国家:
加拿大
项目类别:
财政年份:
2018
资助国家:
加拿大
项目状态:
已结题
起止时间:
2018-08-01 至 2019-08-01
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Telomeres, located at the extremities of our genetic material, safeguards the DNA from aberrant genetic insults. During normal organismal aging, telomere shortening in somatic, differentiated cells acts as a molecular clock to limit cell proliferation, th
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The human telomerase 'Insertion in Fingers Domain' interacts with TPP1 to mediate enzyme processivity and telomerase recruitment to telomeres.