Decoding the impact of critically short telomeres on murine embryonic stem cell transcriptional signatures and cell fate commitment
Decoding the impact of critically short telomeres on murine embryonic stem cell transcriptional signatures and cell fate commitment
批准号:
391487
负责人:
Chu Tsz Wai
金额:
$0.07万
依托单位国家:
加拿大
项目类别:
财政年份:
2018
资助国家:
加拿大
项目状态:
已结题
起止时间:
2018-08-01 至 2019-08-01
关键词:
中文摘要
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英文摘要
Telomeres, located at the extremities of our genetic material, safeguards the DNA from aberrant genetic insults. During normal organismal aging, telomere shortening in somatic, differentiated cells acts as a molecular clock to limit cell proliferation, th
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The human telomerase 'Insertion in Fingers Domain' interacts with TPP1 to mediate enzyme processivity and telomerase recruitment to telomeres.
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批准号:324344
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项目类别:
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资助金额:$0.07万
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财政年份:2015
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负责人:Chu Tsz Wai
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依托单位: