Investigating the mechanics of mRNA decapping in gene silencing

研究基因沉默中 mRNA 脱帽的机制

• 批准号: RGPIN-2015-03712
• 负责人: Fabian, Marc
• 金额: $ 3.13万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=650372
• 关键词: Investigating; mechanics; mRNA; decapping; gene

Controlling the stability of genetic material to regulate biology*******The cellular decapping machinery controls the activity of genetic material (messenger RNA), which in turn serves as the template for the synthesis of proteins in many organisms. It helps regulate most, if not all, biological processes such as fat metabolism, germ cell development and many others. However, it is currently unclear as to how the mRNA decapping machinery interfaces with the numerous mRNAs in each living cell. We are studying how the mRNA decapping machinery interfaces with specific messenger RNAs, and how, once recruited, it targets a mRNA for degradation. We feel confident that our research program will provide important insights into how these fundamental mechanisms operate, and ultimately how they help regulate a variety of biological processes.**

控制遗传物质的稳定性以调节生物学 ** 细胞去帽机制控制遗传物质（信使RNA）的活性，而遗传物质又作为许多生物体中蛋白质合成的模板。 它有助于调节大多数（如果不是全部）生物过程，如脂肪代谢，生殖细胞发育和许多其他过程。 然而，目前尚不清楚mRNA去帽机制如何与每个活细胞中的众多mRNA相互作用。 我们正在研究mRNA去帽机制如何与特定的信使RNA相互作用，以及一旦被招募，它如何靶向mRNA进行降解。 我们相信，我们的研究计划将为这些基本机制如何运作以及最终如何帮助调节各种生物过程提供重要见解。