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Unveiling the role of alpha-synuclein clustering and Lewy body formation in Parkinson's disease pathogenesis using an optogenetic-mediated protein aggregation system

Unveiling the role of alpha-synuclein clustering and Lewy body formation in Parkinson's disease pathogenesis using an optogenetic-mediated protein aggregation system
使用光遗传学介导的蛋白质聚集系统揭示α-突触核蛋白聚集和路易体形成在帕金森病发病机制中的作用
批准号:
389427
负责人:
Oueslati Abid
金额:
$52.94万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2018
资助国家:
加拿大
项目状态:
已结题
起止时间:
2018-09-01 至 2023-09-01

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英文摘要
More than a century ago, the neurologist Friedrich Lewy described for the first time, in the brain of patients suffering from Parkinson's disease (PD), the presence of abnormal protein inclusions, called Lewy bodies (LBs). These inclusions have been sugge
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