Targeting potassium channel to disrupt the cellular hierarchy and suppress malignant growth of pediatric brain tumor

靶向钾通道破坏细胞层次结构并抑制小儿脑肿瘤的恶性生长

• 批准号: 387602
• 负责人: Huang Xi
• 金额: $ 64.93万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-09-01 至 2023-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=387602&lang=en
• 关键词: Brain Tumor; Ion Channel; Mouse Models; Therapeutic Target

Medulloblastoma (MB) is the most common malignant brain tumor in children. The conventional treatment, which combines surgery, irradiation and chemotherapy, is toxic to normal brain cells and produces life-long side effects such as lowered intelligence, e

髓母细胞瘤是儿童最常见的恶性脑肿瘤。传统的治疗方法，结合了手术，放疗和化疗，对正常的脑细胞是有毒的，并产生终身的副作用，如智力下降，