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Determining the etiologies of age-related clonal hematopoiesis (ARCH), a new biomarker of cancer and cardiovascular disease development: focus on the roles of inflammation and genetic predisposition.

Determining the etiologies of age-related clonal hematopoiesis (ARCH), a new biomarker of cancer and cardiovascular disease development: focus on the roles of inflammation and genetic predisposition.
确定年龄相关克隆造血(ARCH)的病因,这是癌症和心血管疾病发展的新生物标志物:重点关注炎症和遗传易感性的作用。
批准号:
390845
负责人:
Busque Lambert
金额:
$69.66万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2018
资助国家:
加拿大
项目状态:
已结题
起止时间:
2018-09-01 至 2023-09-01

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中文摘要
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英文摘要
Aging is associated with the acquisition of small changes (mutations) in the genes of blood cells called Age-Related Clonal Hematopoiesis (ARCH). It seems benign as people have no abnormalities in their blood counts. However, ARCH is associated with a 10-
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C3i - Centre for commercialization of Cancer Immunotherapy
Relationship between clonal architecture of aging hematopoiesis and the risk of developing age-associated myeloid cancers.
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