Activity-dependent reversal of spinal plasticity and pathological pain

脊柱可塑性和病理性疼痛的活动依赖性逆转

• 批准号: 389784
• 负责人: Bonin Robert P
• 金额: $ 54.06万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-09-01 至 2023-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=389784&lang=en
• 关键词: Behaviour; Nmda; Pain; Plasticity; Sensitization; Spinal Cord; Synapse

Intractable, pathological pain is the single most common cause of disability, affecting more than 20% of the population world-wide. Enhanced or abnormal pain sensations that typify chronic pain can arise from cellular changes in sensory processing pathway

顽固性病理性疼痛是导致残疾的最常见原因，影响全球超过20%的人口。感觉加工通路的细胞变化可引起以慢性疼痛为代表的痛觉增强或异常