STAT6-dependent control of innate immunity as a target for therapeutic intervention in asthma

STAT6 依赖的先天免疫控制作为哮喘治疗干预的目标

• 批准号: 390066
• 负责人: Fixman Elizabeth D
• 金额: $ 64.65万
• 依托单位: Research Institute of the McGill University Health Centre
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-09-01 至 2023-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=390066&lang=en
• 关键词: Airway Hyperresponsiveness; Asthma; Innate Immunity; Lung Inflammation; Viral Infection

Both the incidence and severity of asthma have been increasing steadily over the last 2-3 decades. Although asthma in childhood is more prominent in boys, this sex difference changes around the time of puberty, when asthma prevalence declines in men and r

在过去的2- 30年里，哮喘的发病率和严重程度都在稳步增加。虽然儿童期哮喘在男孩中更为突出，但这种性别差异在青春期前后发生变化，此时哮喘患病率在男性中下降，在女性中下降。