Canada Research Chair in Voice Biomechanics and Mechanobiology

加拿大声音生物力学和力学生物学研究主席

• 批准号: 1000229251-2013
• 负责人: Mongeau, Luc
• 金额: $ 14.57万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=660076
• 关键词: Canada; Research; Chair; Voice; Biomechanics

Voice problems constitute the most common communication disorder across the lifespan. These include scarring, atrophy or sulcus vocalis, in which part of the vocal folds is lost or replaced by stiff fibrotic tissue. Bioactive injectable scaffolds promote self-regeneration, which could eliminate the need for periodic clinic visits for re-injection. The goal of the project is to investigate the effects of phonation after injection on the mechanical properties of regenerated tissue, and various scaffold compositions. Cell activity and extracellular matrix protein concentration will be monitored in a bioreactor under phonation-relevant mechanical stress over a time period suitable for neo-tissue growth.

语音问题是整个生命周期中最常见的沟通障碍。这些包括疤痕，萎缩或声带沟，其中部分声带丢失或被僵硬的纤维化组织取代。生物活性可注射支架促进自我再生，这可以消除定期门诊重新注射的需要。该项目的目标是研究注射后发声对再生组织的机械性能和各种支架成分的影响。 将在生物反应器中在适于新组织生长的时间段内在发声相关机械应力下监测细胞活性和细胞外基质蛋白浓度。