Development of treatments for canine parvovirus

在传染病中，犬细小病毒是导致狗的发病率和死亡率的主要原因之一。**感染会导致发烧、呕吐、脱水和腹泻。如果不治疗，大多数狗将死于感染。**目前的治疗方法依赖于昂贵的支持性疗法，如输血、静脉喂养和兽医医院的24小时护理。犬细小病毒感染对狗主人来说是非常昂贵的，其中包括三分之一的加拿大家庭。NovoBind牲畜治疗公司建议开发新的基于抗体的**策略，可提供给狗主人以预防犬细小病毒感染，或提供给**兽医用于治疗受感染的狗。目前，NovoBind正在产生新的犬细小病毒特异性抗体(NBX)。这一建议依赖于Nelly Panté博士和她的实验室在细小病毒生物学和细胞生物学领域的专业知识。这里描述的工作将提供**概念证明，即NovoBind的策略可以阻止犬细小病毒的传染性，并使NovoBind能够**最终选择针对犬细小病毒的最佳抗体。针对犬细小病毒的预防和**治疗产品的开发将使所有狗主人受益，因为它们将为应对犬细小病毒提供更快和**更经济的选择。NovoBind在交付**这一产品时产生的收入也将促进加拿大的经济增长，因为当狗主人不得不放弃工作来照顾他们的狗时，**损失的生产力将会恢复。

Amongst infectious diseases, canine parvovirus is one of the leading causes of morbidity and mortality in dogs.**Infection results in fever, vomiting, dehydration, and diarrhea. Untreated, most dogs will die from the infection.**Current therapies rely on high-cost supportive therapies, such as blood transfusions, IV feeding, and 24-hour**care at veterinary hospitals. Canine parvovirus infections are very costly to dog owners, which includes a third**of Canadian households. NovoBind Livestock Therapeutics Inc. proposes to develop novel antibody-based**strategies that could be provided to dog owners to prevent canine parvovirus infections or be available to**veterinarians as a therapeutic to be administered to infected dogs. Currently, novel canine parvovirus-specific**antibodies (NBXs) are being generated by NovoBind. This proposal relies on the expertise of Dr. Nelly Panté**and her laboratory in the fields of parvovirus biology and cell biology. The work described here will provide**proof-of-concept that NovoBind's strategy can block canine parvovirus infectivity and will enable NovoBind's**eventual selection of the best antibodies against canine parvovirus. The development of prophylactic and**therapeutic products targeting canine parvovirus would benefit all dog owners as they will provide faster and**more economical options for dealing with canine parvovirus. The revenue generated by NovoBind in delivering**this product would also be an economic boost to Canada as would the recovery of lost productivity that occurs**when dog owners must forgo work to care for their dogs.