Identification of new regulators of the innate antiviral response using a genome-scale lentiviral-based RNAi screen.

使用基于慢病毒的基因组规模 RNAi 筛选鉴定先天抗病毒反应的新调节因子。

• 批准号: 198508
• 负责人: Lamarre Daniel
• 金额: $ 7.29万
• 依托单位: Institute for Research in Immunology and Cancer (Montreal, QC)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-09-01 至 2010-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=198508&lang=en
• 关键词: Genome-Wide Screen; Hepatitis C Virus; Innate Immunity; Rnai

The immediate-early phase of the host innate response to viral infection is initiated through pathogen recognition and expression of early protective genes such as type I interferon (IFN). Here, we performed a genome-scale RNA interference screen to ident

宿主对病毒感染的先天反应的早期阶段是通过病原体识别和I型干扰素（IFN）等早期保护基因的表达而启动的。在这里，我们进行了基因组尺度的RNA干扰筛选来识别