Evaluating the relationship between circulating osteoprotegerin levels and bone mineral density in BRCA mutation carriers

评估 BRCA 突变携带者循环骨保护素水平与骨矿物质密度之间的关系

• 批准号: 400387
• 负责人: Hall Elizabeth S
• 金额: $ 0.36万
• 依托单位: Women's College Hospital (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2019-05-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=400387&lang=en
• 关键词: Bone Mineral Density; Brca Mutation Carriers; Breast Cancer; Osteopenia; Osteoporosis; Osteoprotegerin (Opg); Receptor Activator Of Nuclear Factor Kappa-¿ Ligand (Rankl)

Women who inherit a deleterious mutation in the BRCA1 or BRCA2 tumor suppressor genes face a high lifetime risk of breast and ovarian cancer. Recent studies have reported these women also face elevated rates of bone disease (i.e. osteopenia and osteoporos

遗传了 BRCA1 或 BRCA2 肿瘤抑制基因有害突变的女性一生中患乳腺癌和卵巢癌的风险很高。最近的研究报告称，这些女性还面临着骨病发病率升高的问题（即骨质减少和骨质疏松症）