Pathways to neurodegeneration from natural human tRNA variation

人类天然 tRNA 变异导致神经退行性变的途径

• 批准号: 402507
• 负责人: O'Donoghue Patrick
• 金额: $ 63.09万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-03-01 至 2024-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=402507&lang=en
• 关键词: Mutation; Protein Quality Control; Protein Synthesis; Transfer Rna

The ability of cells to properly manage the synthesis, folding, and degradation of their constituent proteins is essential for all aspects of cellular function and life. Many diseases, particularly age-related and neurodegenerative diseases, are character

细胞正确管理其组成蛋白的合成、折叠和降解的能力对于细胞功能和生命的各个方面至关重要。许多疾病，特别是与年龄相关的疾病和神经退行性疾病，都是具有特征性的。