ABERRANT OXYGEN SENSING IN PREECLAMPSIA: CONSEQUENCES AND TARGETING STRATEGIES

先兆子痫中的异常氧传感：后果和目标策略

• 批准号: 401330
• 负责人: Caniggia Isabella
• 金额: $ 68.55万
• 依托单位: Lunenfeld-Tanenbaum Research Institute (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-03-01 至 2024-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=401330&lang=en
• 关键词: Fibronectin; Hif-1 Signalling; Jmjd6 Function; Oxygen Sensing; Phd2 Murine Model Of Preeclampsia; Placenta; Placental Mesenchymal Cells; Preeclampsia; Small Molecule Inhibitors Of Hif-1; Trophoblast Migration/Invasion

Over 400,000 children are born annually in Canada and an estimated 10% of these births will be complicated by preeclampsia (PE) and/or intrauterine growth restriction (IUGR). Such babies are at significantly increased risk of death and serious illness and

加拿大每年有超过40万名儿童出生，其中估计有10%的新生儿会并发先兆子痫(PE)和/或胎儿宫内生长受限(IUGR)。这类婴儿死亡和严重疾病的风险显著增加，