Mechanism of the high-affinity ligand binding and selective ion permeation in voltage-gated K-channels

电压门控 K 通道中高亲和力配体结合和选择性离子渗透的机制

• 批准号: 172724
• 负责人: Noskov Sergei
• 金额: $ 21.86万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Salary Programs
• 财政年份: 2008
• 资助国家: 加拿大
• 起止时间: 2008-09-01 至 2013-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=172724&lang=en
• 关键词: Cardiac Potassium Channels; Membrane Pharmacology; Molecular Biophysics; Molecular Modeling

This project is aimed towards better description of the molecular mechanism, which governs an inhibition of ion currents in cardiac K-channels by the novel anti-arrhythmic and anti-convulsant drugs. Selective transport of potassium ions across cellular

该项目旨在更好地描述新型抗心律失常和抗惊厥药物抑制心脏 K 通道离子电流的分子机制。钾离子跨细胞的选择性运输