Response adaptive designs with multiple objectives

具有多目标的响应自适应设计

• 批准号: RGPIN-2017-04337
• 负责人: Chough, Keumhee
• 金额: $ 1.46万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=677272
• 关键词: Response; adaptive; designs; multiple; objectives

I have spent much of my research career investigating optimal designs that are practically applicable in the real world. My research interests continue to be in constructing optimal designs, while dealing with various practical challenges. Building on my prior work, I plan to further work on building response adaptive designs for binary responses. The project concerns the role of statistical design, modelling, and analysis in quality experiments with repeated measures data. The primary purpose of this project is to continue the development of new statistical tools and methods that address real issues of concern in empirical scientific research. ******Traditionally, optimal design literature has focused on achieving a single objective, namely minimizing the mean square error of the estimated effects. However, considering significant benefits attainable by having multiple objectives satisfied, I find that there is really no going back to the tradition. More research is needed to build optimal designs for small samples adaptively on responses, placing efforts to reassess the optimality and allocating more patients to beneficial treatment(s). As well, response adaptive designs with continuous responses can be benefited by accommodating possible solutions on issues such as measurement errors and missing data methods. ******In our recent work “Multiple-objective response adaptive repeated measure designs in clinical trials for binary responses”, we discussed unique properties in binary designs that arise due to the error matrix being dependent on the parameters. No doubt, this dependency can play a significant role in the resulting optimal design. Misspecification of a covariance matrix may impact the design efficiency, and it will be a focus in this part of my research. Because these experimentations are usually expensive, emphasis is given to techniques and strategies which minimize experimental effort, and maximize information gained from analysis of the results. This research will construct designs that are robust to various experimental conditions with better understanding of possible conflicts between statistical and practical optimality. The foundations of practical optimal designs will be further developed. A variety of other statistical techniques to deal with real issues with repeated measures data will be explored and developed.**

我的研究生涯花了很多时间来研究在现实世界中实际适用的最佳设计。我的研究兴趣仍然是构建最佳设计，同时应对各种实际挑战。在我之前的工作基础上，我计划进一步致力于构建二元响应的响应自适应设计。该项目涉及统计设计、建模和分析在重复测量数据的质量实验中的作用。该项目的主要目的是继续开发新的统计工具和方法，以解决实证科学研究中关注的实际问题。 ******传统上，最优设计文献集中于实现单一目标，即最小化估计效果的均方误差。然而，考虑到通过满足多个目标可以获得的巨大好处，我发现确实没有办法回到传统了。需要更多的研究来为小样本建立自适应响应的最佳设计，努力重新评估最优性并将更多患者分配到有益的治疗。此外，具有连续响应的响应自适应设计可以通过适应测量误差和丢失数据方法等问题的可能解决方案而受益。 ******在我们最近的工作“二元响应临床试验中的多目标响应自适应重复测量设计”中，我们讨论了二元设计中由于误差矩阵依赖于参数而出现的独特属性。毫无疑问，这种依赖性可以在最终的优化设计中发挥重要作用。协方差矩阵的错误指定可能会影响设计效率，这将是我这部分研究的重点。由于这些实验通常成本高昂，因此重点关注最小化实验工作量并最大化从结果分析中获得的信息的技术和策略。这项研究将构建对各种实验条件稳健的设计，更好地理解统计和实际最优性之间可能存在的冲突。实用优化设计的基础将得到进一步发展。将探索和开发各种其他统计技术来处理重复测量数据的实际问题。**