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Actin regulation of ciliogenesis: unraveling novel mechanisms of human ciliopathies caused by mutations in the PCP effector genes

Actin regulation of ciliogenesis: unraveling novel mechanisms of human ciliopathies caused by mutations in the PCP effector genes
肌动蛋白对纤毛发生的调节：揭示 PCP 效应基因突变引起的人类纤毛病的新机制
批准号：
408915
负责人：
Torban Elena
金额：
$56.57万
依托单位：
Research Institute of the McGill University Health Centre
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-09-01 至 2024-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=408915&lang=en
关键词：
Actin Cytoskeleton At The Primary Cilium Actin Regulation Ciliogenesis Drug Testing Ex Vivo, In Vivo And In Vitro Human Ciliopahty Neural Tube Defects Planar Cell Polarity Pathway Polycystic Kidney Disease Protein Interactome Transgenic Mice

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中文摘要
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英文摘要
Some very severe human developmental disorders are caused by dysfunction of the microscopic hair-like structure (primary cilium). Primary cilium projects from most cells in the human body and acts like a "GPS- antenna" to survey the environment outside ce
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  • 批准号：
    372815
  • 项目类别：
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  • 资助金额：
    $1.46万
  • 财政年份：
    2017
  • 负责人：
    Torban Elena
  • 依托单位：
    McGill University
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  • 财政年份：
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  • 负责人：
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  • 依托单位：
    McGill University
Involvement of planar cell polarity pathway in glomerular disease
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