Investigating the role of the BH4 pathway in Parkinson's Disease (PD)

研究 BH4 通路在帕金森病 (PD) 中的作用

• 批准号: 410349
• 负责人: Penninger Josef
• 金额: $ 63.25万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-09-01 至 2024-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=410349&lang=en
• 关键词: Bh4; Bh4 Enhancement; Clarity; Dopaminergic Neurons; Metabolomics/Seahorse Analysis; Mitochondria-Dependent Neuronal Degeneration; Mouse Models; Noradrenergic Neurons; Parkinson'S Disease; Single-Cell Rnaseq

Parkinson's disease (PD) affects 1 in 500 people in Canada; over 100,000 Canadians are living with PD today and ~ 6,600 new cases of PD are diagnosed each year in Canada. PD is the second most common neurodegenerative disorder after Alzheimer's disease. I

帕金森氏症(PD)在加拿大每500人中就有1人受到影响；目前有超过10万加拿大人患有帕金森氏症，加拿大每年新增约6,600例帕金森氏症确诊病例。帕金森病是仅次于阿尔茨海默病的第二大神经退行性疾病。我